Exercise-induced ventricular arrythmia in asymptomatic patients with Mitral Valve Prolapse

Abstract Introduction Mitral Valve Prolapse (MVP) is associated with complex ventricular arrythmia (VA) and sudden cardiac death but risk stratification remains unclear. Exercise induces an hyperadrenergic state could trigger VA, however, data on exercise-induced VA (EIVA) in MVP patients are scarce. Objective To describe EIVA prevalence, origin, characteristics features patients. Methods In this observational prospective study, 64 asymptomatic (58±14 years, 41 men) mild to severe mitral regurgitation (MR) without left (LV) dysfunction, underwent echocardiography symptom-limited exercise testing. Continuous 12-lead ECG monitoring was performed throughout Severe defined as triplets, sustained or non-sustained tachycardia (NSVT) fibrillation. Results All exercised at maximal intensity until exhaustion. observed 54 (84%) subjects including 12 (19%) (7 5 NSVT). originated mainly from the apparatus (all one) occurred high (median 90% of predicted workload) during early recovery phase. Compared rest cohort had similar resting characteristics, LV dimension function, degree MR morphology. Finally, not alteration tolerance. Conclusion frequently unmasks MVP. appears linked nor tolerance seems provide additional phenotyping information that be prognosis. Funding Acknowledgement Type funding sources: None.